Every year thousands of visitors flock to Verona in Italy to visit the famous Capulet House. They leave letters to Juliet in the wall beneath the balcony. Most of these letters are answered by the secretaries of ‘Juliet’, a voluntary organisation and part of the Juliet Club.

Sophie (Amanda Seyfried) travels to Verona with her fiancé, Victor (Gael Garcia Bernal), on what she hopes will be a romantic early honeymoon. But she finds herself spending a lot of time alone as Victor pursues his business contacts. Sophie becomes intrigued with the Juliet Club and begins to help them answer letters.

While working with the Juliet Club, Sophie discovers a letter written 50 years earlier wedged behind a loose brick. She writes to the author of the letter, Claire (Vanessa Redgrave), and is surprised when Claire arrives in Verona with her grandson Charlie (Christopher Egan). To Charlie’s dismay, Sophie has inspired Claire to search for her long-lost love, Lorenzo. Claire left Lorenzo in Italy 50 years earlier, and finding him now will be a challenge. There are hundreds of men named Lorenzo in Italy, but Claire is undeterred. Sophie persuades Claire to let her come on the search. Together with Charlie, they travel the beautiful Tuscany region in their quest to find Lorenzo.