What are selective serotonin reuptake inhibitors (SSRIs)?
Selective serotonin reuptake inhibitors (SSRIs) are antidepressant medications traditionally used to treat depression, anxiety and obsessive compulsive disorder (OCD). Some SSRIs prescribed for autism are fluoxetine (Prozac) and citalopram.
Who are selective serotonin reuptake inhibitors (SSRIs) for?
SSRIs are sometimes used for autistic people who show high levels of anxiety, depression, repetitive behaviour, aggressive behaviour or hyperactive behaviour.
What are selective serotonin reuptake inhibitors (SSRIs) used for?
SSRIs are used to treat depression, anxiety, obsessive compulsive disorder (OCD) and some characteristics of autism, like repetitive behaviour or aggressive behaviour.
Where do selective serotonin reuptake inhibitors (SSRIs) come from?
The first SSRI, fluoxetine (Prozac), was launched in 1987. SSRIs rapidly became the most widely used treatment for depression. They were also found to be helpful in treating OCD and anxiety.
Since the 1980s, researchers have tested SSRIs for use with autistic people who also have anxiety and OCD.
What is the idea behind selective serotonin reuptake inhibitors (SSRIs)?
Serotonin is a neurotransmitter – that is, a chemical messenger that carries messages to and from the brain. It regulates sleep, mood and emotions. Lack of serotonin has been linked to a range of conditions including anxiety and OCD.
SSRIs can be used to help regulate serotonin. Changing the balance of serotonin seems to help brain cells send and receive chemical messages.
SSRIs are an effective treatment for anxiety, which is common among autistic people.
Also, autistic people have some similar characteristics to people with OCD, including repetitive behaviour, special interests and a preference for routines. SSRIs are effective for treating OCD, so researchers believe that they might also improve similar characteristics in autistic people.
What does SSRI therapy involve?
This therapy involves taking oral medication on a daily basis. The specific medication and dosage depends on each child’s symptoms. Children are started on the lowest possible dose.
A medical practitioner, like a GP, paediatrician or psychiatrist, should monitor a child taking SSRIs. The child will need regular appointments with this practitioner, especially during the first four weeks.
The cost of this therapy varies depending on the brand of the selective serotonin reuptake inhibitor (SSRI) and its dose or strength. It also depends on whether the medication is covered by the Pharmaceutical Benefits Scheme (PBS) and whether you have a concession card – for example, a Health Care Card.
Do selective serotonin reuptake inhibitors (SSRIs) work?
Research suggests SSRIs aren’t effective for children, and emerging evidence suggests they can cause harm. But it’s possible that SSRIs might help some autistic adults who also have depression or anxiety.
SSRIs don’t appear to help with the core characteristics of autism.
More high-quality studies are needed.
Who practises this method?
Parent education, training, support and involvement
If your child is taking selective serotonin reuptake inhibitors (SSRIs), you need to ensure your child takes the medication. You also need to monitor the effects, including any rare but serious side effects.
Where can you find a practitioner?
It’s best to speak to your GP, a paediatrician or a child psychiatrist about this therapy.
You can find a child psychiatrist by going to Royal Australian and New Zealand College of Psychiatrists – Find a psychiatrist.
There are many therapies for autism. They range from those based on behaviour and development to those based on medicine or alternative therapy. Our article on types of interventions for autistic children takes you through the main therapies, so you can better understand your child’s options.